Updates to the Management of Acetaminophen Poisoning

Recently, new guidelines were published for the management of acetaminophen poisoning. These guidelines suggested a new toxic dose, made recommendations for when to start and stop acetylcysteine empirically, and other changes. Additionally, many people are using fomepizole and high-dose n-acetylcysteine for the treatment of acetaminophen poisoning, but the data are quite limited. Finally, emerging evidence suggests that prolonged administration of acetylcysteine may actually be harmful. This presentation will address these updates, alternative therapies, and emerging data.