• Webinar Details

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But I Don't Dispense Those! A Community Pharmacist's Guide to Immuno-Oncology Agents

Event Type

Live Online

Date

Monday, July 16, 2018

Time

10:30 AM - 12:00 PM ET

Location

PharmCon Webinar Studio (freeCE.com)

Credits

1.5 Contact Hour(s)

Target Audience

Nurse, Pharmacist

Cost

$0.00

  • Overview

    The promise of the immune system in helping to treat cancer has finally become a reality in the past few years. The immune system is designed to differentiate between normal cells  foreign cells.  To do this, it uses “checkpoints” – molecules on certain immune cells that need to be activated (or inactivated) to start an immune response.  Cancer cells often may look like normal cells and may evade the immune system recognition.  An important molecule in this process is CTLA4 and thus a CTLA4 antagonist has been developed to help T cells recognize cancer cells better.  Once the T cells finds the cancer cell another checkpoint is the molecule PD-1 on the T cell which binds to the PD-L1 receptor on the Cancer cell which will cause destruction of the T cell.  This appears to be a major reason why T cells have difficulty killing cancer cells.  Both PD-1 and PD-L1 inhibitors have now been established and have good effects in a variety of cancers including melanoma of the skin, non-small cell lung cancer, kidney cancer, bladder cancer, head and neck cancers,  Hodgkin lymphoma, bladder cancer, non-small cell lung cancer, and Merkel cell skin cancer.

    Since these drugs inhibit normal checkpoints the problem is they may allow T cells to now recognize normal cells as being foreign, which can lead to serious side effects commonly behaving as autoimmune disease.

    The newest agents in the immunology-oncology field are Chimeric Antigen Receptor T cells, in which the patients own T cells are genetically modified to produce a receptor for a target on the T cell.  Currently approved agents express CD19 and are approved for relapsed/refractory ALL and DLBCL.  These are extremely exciting agents which may have the potential for long term remission of cancer.  One problem is if the T cells expand too rapidly they release cytokines, called “Cytokine Storm” which can be life threatening. Thus it is critical pharmacists have a good understanding of the mechanisms and adverse events associated with all of these therapies and a good understanding of how to manage the side effects.

    30 days following this live webinar, participants will be invited to participate in a 30-minute follow-up home study (0.5 credit hour) that will provide the opportunity to review the main concepts from the webinar and apply what has been learned to patient cases related to immuno-oncology agents.



    Rating


    Handouts

    Slide Document:   18099L01_4pp.pdf


    Slide Document:   18099L01_2pp.pdf

    Financial Support By

    Merck & Co., Inc.
  • Nurse

    Identify current FDA approved PD-1, PD-L1 and CTLA4 Inhibitors as well as Chimeric Antigen T cells and their indications and their place in therapy.
    Describe the mechanism of action of these immunologic agents
    Describe the symptoms of the adverse events of these agents and potential management strategies


    Pharmacist

    Identify current FDA approved PD-1, PD-L1 and CTLA4 Inhibitors as well as Chimeric Antigen T cells and their indications and their place in therapy.
    Describe the mechanism of action of these immunologic agents
    Describe the symptoms of the adverse events of these agents and potential management strategies
    Understand the pharmacist's role in communicating recommendations in caring for patients on these agents

  • Repeat Presentation

    This is a first run presentation.

    Future Airings

    DateTime 
    Monday, December 3, 20188:00 PMView
    Monday, December 17, 201810:30 AMView
    Tuesday, January 15, 20198:00 PMView

  • Activity Type

    Application

    Universal Activity Number

    Nurse 0798-0000-18-099-L01-P

    Pharmacist 0798-0000-18-099-L01-P

    ACPE PharmCon, Inc. is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

    PharmCon, Inc. is an approved course provider for continuing education for nurses by the Florida Board of Nursing. PharmCon is also recognized by the California Board of Nursing as a provider of nursing programs.

    In order to obtain a Statement of Credit, attendees must answer poll questions and complete a program evaluation. Attendees may immediately print their Statement of Credit or leave them stored on the website.

  • Faculty

    David Frame, PharmD
    Assistant Professor, University of Michigan College of Pharmacy




HARDWARE REQUIREMENTS
Standard Windows/Mac System
iPad or iPhone
Minimum screen resolution: 1024x768
Speakers or headphones
 


SOFTWARE REQUIREMENTS
Microsoft Edge
Internet Explorer 8.0 or higher
Google Chrome
Safari
Firefox 3.0.3 or higher


NETWORK REQUIREMENTS
Broadband Internet Connection:
T1, Hi-speed DSL or Cable
4G cellular connection
 
 

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Computer sharing is NOT permitted due to accreditation guidelines on activity monitoring. Credit is earned by one user per device.

 

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