In 2022, a total of 37 novel drugs were approved by the FDA. New approvals have the potential to change the landscape for disease state management or simply become another choice in the arsenal of options. Either way, it is essential that the healthcare provider understand the new indications, adverse effects, and potential interactions and risks associated with these new players. In this session, newly approved drugs, ranging in specialties from multiple sclerosis to diabetes to carcinomas and beyond are examined from the lens of a pharmacist. The session will focus on notable approvals expected to impact pharmacy practice most significantly, while providing an overview of drugs approvals for more rare diseases as well.